Abnormal DISC1 has been proposed to augment the risk of schizophrenia, bipolar disorders, and recurrent major depression (Kirkpatrick et al., 2006; Carlisle et al., 2011), especially when combined with environmental stressors acting at different developmental time points (van Os and Kapur, 2009; Insel, 2010). The gene discussed is DISC1; the disease is schizophrenia.