Furthermore, increased glutamate receptor levels and age‐dependent aberrant neuronal excitability have been observed in C9orf72 NRE‐linked ALS/FTD in vitro models, animal models, and/or patients (Selvaraj et al, 2018; Starr:2018fv Shi et al, 2018), and we demonstrate through our neuronal excitotoxic stress and neuronal activity experiments that increased neuronal excitability increases non‐AUG‐dependent translation of the C9orf72 NRE. The gene discussed is C9orf72; the disease is frontotemporal dementia.