C9orf72 and neurodegenerative disease: Therefore, given the C9orf72 gene transcripts are most abundant in the brain of human post‐mortem tissue (Carithers et al, 2015), it may not be surprising that C9orf72 NRE DPRs are more readily detected within these regions that are directly linked to neurodegenerative disease (Saberi et al, 2018).