C9orf72 and amyotrophic lateral sclerosis: In summary, this work identified drivers of and cell type‐specific differences for non‐AUG‐dependent translation of the ALS/FTD‐linked C9orf72 NRE, and we uncovered novel therapeutic candidates that may be quickly repurposed to begin treating neurodegeneration caused by non‐AUG‐dependent translation of NRE mutations.