Specifically, we found that deleting Stat3 in the majority astrocytes induced a higher complexity of microglia around Aβ plaques, reduced amyloidosis and soluble Aβ, increased the internalization of Aβ by microglia, attenuated neuroinflammation, and normalized network homeostasis, ultimately resulting in lower dystrophic neurite burden and a better cognitive outcome. This evidence concerns the gene STAT3 and amyloidosis.