PSEN1 and Mental deterioration: In line with this, the whole‐brain levels of the pro‐inflammatory cytokines IL‐1β and TNF‐α, which have both been associated with the progression of Aβ deposition, neurodegeneration, and cognitive decline in AD (Heneka et al, 2015), were reduced in APP/PS1‐Stat3KO compared to APP/PS1‐Stat3WT mice (Fig 5G).