STAT3 and Alzheimer disease: The pathways underlying this mechanism remain to be elucidated, but may be related to the fact that P2Y1 receptors—which are important mediators of network imbalance in AD (Delekate et al, 2014; Reichenbach et al, 2018)—as well as downstream astroglial calcium changes may activate astrogliosis and astrocytic Stat3 (Washburn & Neary, 2006; Kanemaru et al, 2013).