STAT3 and multiple sclerosis: JAK/Stat3 activation in astrocytes has been detected in a plethora of conditions and disease models that are associated with astrogliosis, including stroke (Justicia et al, 2000), AD (Ben Haim et al, 2015), spinal cord injury (Okada et al, 2006; Herrmann et al, 2008), multiple sclerosis (Qin et al, 2012), and epilepsy (Xu et al, 2011).