Additionally, p16INK4A+ fibroblasts and epithelial cells with telomere-associated DNA damage foci (TAFs), another marker of cellular senescence, accumulated in fibrotic regions of honeycomb lung in patients with IPF, together with increased expression of SASP components (including the matrix remodeling proteins and pro-inflammatory factors that were tested in the blood of subjects in the present study) [5]. Here, CDKN2A is linked to idiopathic pulmonary fibrosis.