As shown in Figure 6B, almost 29% of all WS-causing mutations (adjusted for differences in mutation rates between the three pathways) were due to an identical 33 base pair in-frame deletion in awsX (Δt229-g261, ΔY77-Q87), while a further 13% were due to an identical mutation (79 a->c, T27P) in awsR. At least 41 different mutations in Aws lead to WS: if mutation rates were equal for these sites the probability of observing 20 identical mutations would be extremely small. Here, JAG1 is linked to Werner syndrome.