The LPS activation significantly increased the combined expression of M1 phenotype markers (CD68 + CCR2, CD68 + CXCR1, CD68 + IL12, CD68 + iNOS and CD68+ TNFa) and M2 phenotype markers (CD68 + ARGINASE1, CD68 + IL10, and CD68 + DECTIN1) in EHT; whereas there were non-significant effects on the activated M1 or M2 macrophage phenotypes in GD samples (Fig. 4b and d). Here, CCR2 is linked to essential hypertension, genetic.