Compared with healthy controls, we identified a significantly higher level of citH3-DNA, NE-DNA, and MPO-DNA complexes in sera from AOSD patients (Fig. 1a; P < 0.01, P < 0.001, and P < 0.001, respectively), suggesting that circulating nucleosomes are, at least in part, derived from NET release. The gene discussed is MPO; the disease is adult-onset Still disease.