In the current study we assessed retinal tau pathology in the rTg(tauP301L)4510 mouse model, which harbours the same P301L mutant form of the human MAPT gene previously described in the study by Ho et al. [19], but driven by the forebrain-specific calmodulin kinase II a (CaMKIIa) promoter system, which results in NFT pathology in forebrain structures and the hippocampus, reminiscent of the pattern for tau accumulation observed in FTD [20, 41, 46]. Here, MAPT is linked to frontotemporal dementia.