Finally, our global study identifies the importance of TET-mediated 5-hmC enrichment in regulating the differential expression of three oncogenes: NSMCE1, TUBGCP3 and TUBGCP6. NSMCE1 gene was shown to play key roles in the maintenance of chromosome integrity during mitotic proliferation, meiosis, and DNA repair and is critical for genome stability [40] whereas TUBGCP6 and TUBGCP3 genes were shown to be over-expressed in glioblastoma [41]. Here, NSMCE1 is linked to glioblastoma.