TLR4 and autoimmune polyendocrinopathy: In light of the growing evidence of the role of innate immunity, and TLR-4 in particular, in the pathogenesis of thrombosis in APS, we sought to investigate the plasma level of sTREM-1 in a cohort of patients with PAPS, the clinical association of sTREM-1 with thrombotic PAPS, and the possible use of sTREM-1 as a biomarker of thrombotic events in PAPS.