CRP and autoimmune polyendocrinopathy: Previous findings in patients with APS of elevated levels of inflammatory markers, including CRP and serum amyloid-A [20–25] relative to controls, as well as activated monocytes [26] and increased production of proinflammatory cytokines relative to controls [27, 28], suggest that PAPS is associated with a low-grade inflammatory state and an innate immune response.