CD40LG and autoimmune polyendocrinopathy: Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombotic events and/or pregnancy morbidity in the presence of persistent antiphospholipid antibodies (APLA), namely lupus anticoagulant (LAC), anticardiolipin (aCL) IgG and/or IgM antibodies, and/or anti-β2 glycoprotein I (β2GPI) IgG and/or IgM antibodies [1].