Genes differing between conditions in their histone modification profiles encode proteins involved in apoptosis (IAP3 and IAP7), Clip-domain serine proteases and serine protease inhibitors (CLIPC, CLIPE, SRPN10 and SRPN4), C-type lectins (CTLs) (Fig. 2e), antimicrobial peptides (DEF1) (Fig. 2f), scavenger receptor (SRCR domain) with lysyl oxidase domain (SCRAL1) and components of Toll, NF and peptidoglycan recognition protein LC/immune deficiency (PGRP-LC/IMD) signaling pathways (Additional file 4: Figure S4A–C, Additional file 5: Table S4). Here, XIAP is linked to Immunodeficiency.