MGMT and gastrointestinal stromal tumor: However, one of these papers dealt exclusively with gastric cases [15], which are expectedly enriched in SDH-deficient GISTs, albeit presumably not at a level to justify per se the detected prevalence of MGMT-methylation (of note, SDH status was not investigated, coherently with the epoch of the study, which preceded the discovery of the role of SDH in GIST pathogenesis [42]).