Western blot results showed that neutrophils promoted the phosphorylation of JAK2 (P < 0.05 and P < 0.05 in MKN45 and MKN74 cells, respectively) and STAT3 (P < 0.05 and P < 0.05 in MKN45 and MKN74 cells, respectively) but had no significant effect on the expression of JAK2 and STAT3 in GC cells (MKN45 and MKN74) (Fig. 5a and b). Here, STAT3 is linked to gastric cancer.