Studies on ischemic AKI mouse model have demonstrated that intravenous injection of EVs of human umbilical cord blood-derived endothelial cell colony-forming cells and highly proliferative and angiogenic EPC could attenuated renal injury through improvement in the necrosis and of apoptosis of renal TEC; moreover, these EVs containing miR-486-5p were found to target at PTEN/Akt pathway through transferring miRNA to ECs, leading to reduction in renal PTEN level and activation of Akt, thereby protecting kidney against ischemia reperfusion injury (IRI) (Fig. 1, Table 1) [56–58]. The gene discussed is PTEN; the disease is ischemia reperfusion injury.