In renal cancer, renal cancer stem cell-derived EVs have shown to inhibit the differentiation process of dendritic cells (DCs) from monocytes through significantly attenuating the expression of HLA-G, costimulatory molecules, and adhesion molecules that lead to immune suppression, favoring tumor immune escape that leads to immune tolerance (Fig. 1, Table 1) [76]. The gene discussed is HLA-G; the disease is renal carcinoma.