Given that thousands of proteins participate in the cell division cycle [72], the specific identification of BUB1, NCAPG, CDK1, and MELK as predictors of BCR, as well as key targets of MIR145-3P that are associated with CRPC, suggests a particularly important role for these cell cycle/mitosis genes in aggressive PCa. This evidence concerns the gene BUB1 and posterior cortical atrophy.