A randomized controlled trial of EN versus parenteral nutrition in 50 patients with severe pancreatitis showed that EN was not associated with changes in IL-6, IL-8 or CRP.[18] A study randomized 20 ICU patients to either receive EN alone or similar EN feeding with supplemental parenteral nutrition to increase caloric intake for 7 days and found that IL-1, IL-6 and TNF-α measured on days of 0, 3 and 7 did not differ between the two groups.[19]. This evidence concerns the gene IL1B and pancreatitis.