On the other hand, certain proteins were exclusively detected in EVs under loperamide-treatment such as TSG101 (exosomal marker tumour susceptibility), EPS8-like protein (as part of epidermal growth factor receptor (EGFR) signalling), prominin-1 (CD133, a pentaspan protein) and the transforming growth factor-beta-induced protein ig-h3 (TGFBI, also known as keratoepithelin). This evidence concerns the gene TSG101 and neoplasm.