On the other hand, proteins exclusively detected in sEVs under loperamide-treatment included TSG101, which has been previously reported to increase after cancer chemotherapy [57], and several other proteins such as EPS8-like protein, prominin-1, TGFBI and CDC42-interacting protein, which could induce migration and cell proliferation between the host and the parasite [58–60]. The gene discussed is PROM1; the disease is cancer.