PAPPA and heart failure: The variables selected, in decreasing order of importance, were BNP, age, FGF-23, IL-27, PAPPA, TRAIL-R2, PIGF, SCF, VEGF-D, CXCL1, IL-18, IL-1ra, RAGE, PAR-1, CCL3, TM, TIE2, ADM, PSGL-1, SRC, HB-EGF, PDGF subunit B, eGFR, sex, and heart failure (Figure 5).