In thyroid cancer, high HMGA1 expression can be used as a diagnostic marker of thyroid follicular cancer to distinguish between nodular thyroid and thyroid cancer.29 It was reported that HMGA1 has a vital role in thyroid tissue through inhibition of p5350 and HAND151 and induction of TGF‐β152 and S100A13.53 The HMGA1P6 and HMGA1P7 also functions in promoting the malignant progression of thyroid cancer.54 This evidence concerns the gene HMGA1 and thyroid gland carcinoma.