In pituitary tumours, Wang et al reported that an increased expression of HMGA1 in pituitary adenomas, whereas in normal tissues it was negative, and HMGA1 was significantly more expressed in invasive adenomas.25 In gliomas, Pang et al and Donato et al revealed that HMGA1 expression was increased in gliomas compared with normal adjacent tissue; however, expression was lower than in glioblastomas. This evidence concerns the gene HMGA1 and central nervous system cancer.