First, HMGA1 can induce chromosomal instability in CRC by the regulation of spindle assembly checkpoint genes, such as Ttk, Mad2l1, Bub1 and Bub1b.70 Second, miRNAs, such as miR‐137, miR‐138 and miR‐214, have important roles in inhibiting the function of HMGA1 and suppressing CRC progression.21, 22, 71 Third, Wnt/β‐catenin signalling is a classical pathway to promote tumourigenesis in colorectal cancer. The gene discussed is MAD2L1; the disease is colorectal carcinoma.