This finding is notable because faecal metabolomic analysis can serve as a non‐invasive screening tool in the early precursor lesions of colorectal cancer.24 In the regulation of metabolites, HMGA1 contributes to CRC by inducing fatty acid synthesis and aerobic glycolysis.10, 23 Above all, we are certain that HMGA1 can be used as a diagnostic indicator of CRC. The gene discussed is HMGA1; the disease is colorectal cancer.