PTGS2 and cervical cancer: Additionally, these studies found that HMGA1a binds directly to the COX‐2 promoter based on chromatin immunoprecipitation.97 At the same time, Di Cello et al also demonstrated that COX‐2 inhibitors can rescue the role of HMGA1 in cervical cancer.98 Cervical cancer growth is impaired in an matrix metalloproteinase‐2 (MMP‐2) deficient background in HMGA1a transgenic mice.