The data show that HMGA1 can regulate Wnt signalling to promote CRC progression and “build” an intestinal stem cell niche through inducing SOX9, interacting with β‐catenin and specifically binding to the β‐catenin/TCF‐4 complex.20 Lastly, HMGA1 regulates the symmetric/asymmetric cell division ratio and self‐renewal in CSCs through transcriptional regulation of p53.72 However, HMGA1‐relevant small molecule compounds or drugs are rarely reported. Here, HMGA1 is linked to colorectal carcinoma.