HIF1A and hepatocellular carcinoma: In contrast, another recent data showed that Sirt1 interacts with HIF‐1α and the deacetylation of HIF‐1α stabilizes HIF‐1α protein expression and promotes its activity using human hepatoma cell lines such as Hep3B, HepG2, and Huh7 cells (Laemmle et al., 2012).