The renal protective effects of Sirt1 have been shown in multiple disease models including aged kidney (Kitada, Kume, Takeda‐Watanabe, Kanasaki, & Koya, 2013; Kume et al., 2010), acute kidney injury induced by ischemia reperfusion (Funk & Schnellmann, 2013) or cisplatin (Hasegawa et al., 2010), unilateral ureteral obstruction (UUO; He et al., 2010), and diabetic nephropathy (Chuang et al., 2011; Liu et al., 2014; Shang et al., 2013). This evidence concerns the gene SIRT1 and Ureteral obstruction.