In contrast, another recent data showed that Sirt1 interacts with HIF‐1α and the deacetylation of HIF‐1α stabilizes HIF‐1α protein expression and promotes its activity using human hepatoma cell lines such as Hep3B, HepG2, and Huh7 cells (Laemmle et al., 2012). The gene discussed is SIRT1; the disease is hepatocellular carcinoma.