miR‐125b was demonstrated to be up‐regulated in the CNS of SOD1‐G93A mice, correlating with neurodegeneration and astrocytosis.38 miR‐125b and miR‐155 levels were also augmented in the microglia of SOD1G93A mice, where they promote neuroinflammation.39 Increased miR‐155 expression was demonstrated in the ALS spinal cord, with a fivefold increase in rodent and twofold increase in patients samples.40 Anti‐miR‐155 prompted generalized de‐repression of mRNA targets in peritoneal macrophages and was found to disseminate in the mouse brain and spinal cord after intraventricular delivery. Here, SOD1 is linked to amyotrophic lateral sclerosis.