CD4 and tuberculosis: 194 IVE-TB highly expressed genes were identified and 50 further selected based on ranking in the top 15% during infection; hyperconservation with wide HLA coverage and/or homology withMycobacterium leprae. Many of these IVE-TB antigens were found to induce strong CD4+ T central memory and CD8+ T-cell responses in PBMCs from long-term, latentlyMtb infected individuals, and were recognized by both T- and B- cells69.