An investigation of other responses, including proliferative and cytokine profiles besides IFN-γ, in a cohort of healthy Dutch individuals with PPD and/or ESAT6+CFP10in vitro responses, and in a cohort of Norwegian individuals with LTBI, demonstrated that many IVE-TB antigens induce cytokines other than IFN-γ71. The gene discussed is IFNG; the disease is tuberculosis.