Accordingly, exploring the role of unconventional T-cells and T-cell responses, such as donor unrestricted T-cells (DURTS), mostly CD8+ T-cells restricted by CD1, MR1, HLA-E, TCR-gamma-delta; non-IFN-γ producing T-cells; and the role of non-T-cells will be critical to future TB vaccine development efforts57,65. The gene discussed is CD8A; the disease is tuberculosis.