Many of them are Wnt direct target genes, overlapping with target genes listed on the Wnt homepage (https://web.stanford.edu/group/nusselab/cgi-bin/wnt/target_genes, last updated May, 2018) Among these altered genes, Wnt antagonists FRZB, SFRP1, and WIF1 were decreased in tumor samples while Wnt ligands WNT5A, FZD1, DVL3 and target transcription factors CCND1, MYCB, SNAI2 were increased in tumor samples (Figure 6A). Here, FZD1 is linked to neoplasm.