POU4F2 and neoplasm: Although the implications of such distinct expression patterns are still to be elucidated, previous studies have shown that Brn-3b(s) is increased in breast cancers or neuroblastoma tumours and its overexpression in breast cancer or neuroblastoma derived cell lines is sufficient to enhance growth and transformation [10, 11] but also confer resistance to chemotherapeutic drugs including cisplatin and doxorubicin [12].