A possible mechanism is that the ZNF350/BRCA1/CtTB-interacting protein complex represses the expression of angiopoietin-1 (ANG1) and high-mobility group AT-hook 2 (HMGA2), which are commonly involved in the proliferation and vascularization during breast tumor formation [31, 32]. This evidence concerns the gene ANGPT1 and breast neoplasm.