CRBPI transfection in A549 lung cancer cells up-regulated proliferative and transcriptional genes, including pAKT, pEGFR, pErk1/2, creb1 and c-jun [38]; among these, FABP5 and PPRβ/δ trigger inflammatory changes and the deregulation of proliferation [19, 43]. The gene discussed is CREB1; the disease is lung cancer.