Furthermore, dependence on the PRMT5 catalytic activity for this interaction revealed in fact that PRMT5 symmetrically methylates SREBP1a on R321, which prevents its phosphorylation on serine 430 by GSK3β and increases its transcriptional activity, thereby enhancing lipogenesis in hepatocellular carcinoma [51]. Here, SREBF1 is linked to hepatocellular carcinoma.