So, while it is justified to develop very potent PRMT5-specific inhibitors to treat various types of cancer, rigorous testing in cell culture and animal models should be done to rule out the adverse effects PRMT5 inhibition might have on other vital processes such as embryogenesis, spermatogenesis, neurogenesis, muscle regeneration, adult hematopoiesis and immune response. The gene discussed is PRMT5; the disease is cancer.