CCNE1 and breast carcinoma: In accord with these results, breast cancer gene array profiling indicated that elevated expression of KLF4 in both MCF10A and MCF7 breast cancer cell lines upregulates transcription of several oncogenes and cell cycle activators such as MAPK, EGF/EGFR, IGF1, CYCLIN D2, CDK1, and CYCLIN E1.