SREBF1 and clear cell renal carcinoma: In another study, it was shown that SREBP1c overexpression correlates with high expression of lipogenic genes in clear cell Renal Cell Carcinoma (ccRCC), and that it is downregulated by the ring finger protein 20 (RNF20), which contains a ring finger-containing E3 ubiquitin ligase activity that promotes SREBP1c polyubiquitination and subsequent degradation [52].