The role-played by PRMT5 in the onset and progression of cancer is becoming more and more clear as previous work by Wei and colleagues showed that ectopic expression of PRMT5 is associated with upregulation of the G1 phase cyclins D1, D2, and E1, as well as cyclin-dependent kinases (CDK) 4 and 6 [44]. The gene discussed is PRMT5; the disease is cancer.