In a more recent study, PRMT5 has been shown to be overexpressed in a large cohort of human gastric tumors and to contribute to increased recruitment of DNA methyltransferase 3A (DNMT3A) to the promoter region of the tumor suppressor gene, Iroquois homeobox 1 (IRX1), in gastric cancer cells. This evidence concerns the gene IRX1 and gastric neoplasm.