HOXA5 and cancer: Therefore, a consequence of PRMT5-mediated inhibition of the RB family of tumor suppressor proteins is elevated expression of PRC2 subunits as well as increased PRC2 methyltransferase activity, which in turn promotes cancer cell growth and proliferation through suppression of anti-cancer genes including pro-apoptotic target genes CASP10, DAP1, HOXA5, and HRK [34].