Furthermore, histopathological analysis of excised tumors from NSG (NOD/Scid/IL-2Rγnull) mice injected with either control or PRMT5 knock down BCSCs showed that reduced PRMT5 expression results in a more differentiated and less aggressive breast cancer phenotype compared to control tumors, indicating that PRMT5 promotes breast cancer cell stemness by suppressing differentiation. This evidence concerns the gene PRMT5 and breast cancer.