Poly (A:U) transfection produced a less pronounced increase in cytokine expression, suggesting that while TLR3 is certainly involved in dsRNA-induced signaling that results in increased cytokine production, other receptors (such as MDA5 or PKR) are also part of this process in this mouse epithelial ovarian tumor cell line. The gene discussed is EIF2AK2; the disease is ovarian epithelial tumor.