TLR4 and ovarian cancer: We also determined that murine ovarian cancer cells express other PRRs at the RNA level, including TLR2, TLR4 and TLR7, indicating that several innate immune inflammatory pathways can be activated in these cells (Supplementary Figure 1D) in response to microbial molecules from microbial pathogens, microbes the oncobiome or microbial products in circulation as a result of intestinal dysbiosis.