Patients with Graves’ disease (GD) show increased kynurenine to Trp ratios and have increased IDO expression in B cells and dendritic cells (DCs), indicating immune suppression; however, GD-derived CD4+ T cells have increased WRS expression and their proliferation was not inhibited by IDO expression in DCs from GD-patients, suggesting the activation of autoreactive T cells80. The gene discussed is IDO1; the disease is Graves disease.