IL6 and Anxiety: We observed significant negative correlations between the plasma levels of Cxcl1, G-Csf, and Mig and different anxiety-like measurements in AP-treated HFD mice (Figures 3I–3K and S3C) and D+Q-treated db/db mice (Figures S3D and S3E), whereas no correlation was found for Tnf-α, Il-6, and Mcp-1 (Figures S3F–S3H).