In that report, Xie and his colleagues found that ARF could stabilize Slug through interacting with SUMO molecule at lysine residue 192 (K192), modulate the Slug/E-cadherin signaling, and augment prostate tumorigenesis in vivo; the regulation mechanisms of Slug SUMOylation are different with our findings. This evidence concerns the gene CDKN2A and male reproductive organ cancer.