As expected, HDAC1 more strongly associated with the E-cadherin promoter in cells overexpressing wild-type Slug and Ubc9 than in Slug5M and Ubc9 (Fig. 4f); and this result was also re-confirmed in human lung adenocarcinoma cell line, Hop62 (Additional file 8: Figure S8). This evidence concerns the gene UBE2I and lung adenocarcinoma.