ERBB2 and breast cancer: No known ligand has been identified for ERBB2, ethanol induces its phosphorylation that activates the mitogen-activated protein kinase MAPK signaling members, extracellular signal-regulated kinase ERK and other several important signaling cascades well-known to be downstream target of ERBB2 that play a key role in the carcinogenesis and aggressiveness of breast cancer [40].