GSTM1 and cardiovascular disorder: One study showed that restrictive transfusion (transfusion trigger: Hb < 8 g/dl) could not improve the survival rate, especially in a high-risk group of elderly patients with cardiovascular disease [48], and our meta-analysis showed that restrictive (transfusion trigger: Hb ≤ 6 g/dl) or liberal transfusion (transfusion trigger: Hb ≤ 7–10 g/dl) could decrease the OS significantly compared with non-transfusion.