In a post-hoc analysis, Zinman et al. investigated the CV safety of linagliptin as an insulin add-on in patients with T2DM [25] and found a neutral effect on major CV events (linagliptin 27 vs. placebo 24 events) and overall mortality (8 deaths in 811 patients vs. 8 deaths in 802 patients). The gene discussed is INS; the disease is type 2 diabetes mellitus.