Used endogenous inhibitor as an anticancer mechanism clue in this study, TIMP-2 has many distinct properties and functions independent of MMP inhibition, including inhibition of tumor growth and reduction of angiogenesis through decreased endothelial cell proliferation and migration by interacting with alpha3 beta1 (α3β1) integrin on endothelial cells [11]. This evidence concerns the gene TIMP2 and neoplasm.