NLRP3 and major depressive disorder: In conclusion, it is clear that the discovery of the role of NLRP3 inflammasome activation in the mechanisms of antidepressant action has opened an array of research opportunities to investigate inflammasome-targeted therapies for depression and other pathological changes in the brain; however, further study in larger populations examining the impact of these antidepressants on the assembly of the NLRP3 inflammasome is urgently needed.