In addition, the TP53 and Casp-3 genes were found to be up-regulated in glioma cells after exposure to this extract; these proteins play an important role in tumor suppression, cell cycle arrest and the execution-phase of cell apoptosis (Delbridge et al. 2012; Li et al. 2012; Guo et al. 2014). This evidence concerns the gene CASP3 and neoplasm.