One such ligand is [18F]flortaucipir (formerly known as [18F]T-807 and [18F]AV1451) [2, 3], and studies examining the relationship between [18F]flortaucipir uptake and CSF tau levels have shown modest positive correlations in cognitively unimpaired older adults and in patients with AD and non-AD neurodegenerative disorders [4–7]. This evidence concerns the gene MAPT and Alzheimer disease.