MAPT and Alzheimer disease: Specifically, a significant interaction was observed between CSF tau measures and isocortical metabolism ([18F]FDG SUVR) whereby those with higher metabolism (SUVR >1.4; n = 7, five prodromal AD, two AD dementia) showed positive slopes for the above-described associations, while those with more impaired metabolism (SUVR <1.4; n = 6, four prodromal AD, two AD dementia) showed negative slopes, similar to the findings observed at the group level (in analyses using ratios, the additional AD dementia subject had an SUVR >1.4; Online Resource 6).