SATB2 and acute lymphoblastic leukemia: In summary, this report highlights the role of aPKC in B-cell precursor leukemogenesis and unveils the role of SATB2 -dependent transcriptional repression activity in the specific development of B-ALL, with profound mechanistic and translational implications, in both our understanding of the process of leukemogenesis and the identification of alternative targets for Ph+-, and probably Ph-like, leukemias.