PLCE1 knockdown in infected Eca109 and EC9706 ESCC cells increased the effects of NF-κB inhibitor, reducing HUVEC proliferation and ESCC cells’ ability to induce tubule formation and migration by HUVECs in vitro (P < 0.05, Fig. 5g-k, Additional file 5: Figure S4c). The gene discussed is PLCE1; the disease is esophageal squamous cell carcinoma.