AKT1 and infection: As for the β-catenin signaling, other virulence factors released in the extracellular gut milieu during a pathogenic infection, can potentially induce cancer transformation when infecting pre-transformed cells, through the activation of other pro-survival intrinsic host’s cellular pathways, such as MAPK and AKT, as for CagA from Helicobacter pylori, controlling the hosts MAPK pathway or AvrA from Salmonella enterica, triggering both MAPK and AKT pathways [71,72].