TRPM8 and Familial prostate cancer: Previous imaging and single cell studies investigated K+, Na+ and Ca2+ channels in human prostate cancer basal activity and proliferation [22,23] Consensus on the role of Ca2+ channels during prostate cancer proliferation seems to exist as demonstrated by Zhang and colleagues through the use of Ca2+-permeable channel TRPM8 [24,25] and by others trough a permeable channel to Ca2+, TRPC6 [26] and other oxidative stresses [27].