Furthermore, Zhu et al. with a background of previous accounts on the role of β-elemene in arresting glioblastoma cells (U87 and C6) in G0/G 1 phase, showed that by regulating the glia mutation factor β/mitogen activated protein kinase 3/6/p38 and extracellular signal regulated kinase 1/2/B cell lymphoma 2/surviving pathways, inhibition of cell proliferation was facilitated and promotion of in vitro and in vivo differentiation of glioblastoma stem cells (GSCs). The gene discussed is MAP3K3; the disease is glioblastoma.