CCNB1 and lung cancer: These lung cancer cells were arrested at the G2-M phase, which caused a decrease in levels of phosphor- cell division cycle (cdc)2 (Thr-161) and cyclin B1, with an increase in the levels of phosphor-cdc2 (Tyr-15) p27kip1 and partially by the check point kinase (CHK)2-dependent mechanism [48].