Recently, Kouroupi and coauthors [209] described a significant reduction of synapsin III in induced pluripotent stem cell (iPSC)-derived neurons from A53T mutant patients, while we did not observe any particular difference in synapsin III expression between iPSC-derived dopaminergic neurons from MSA patients, which only showed a slight and non-significant increase of α-syn levels [210]. This evidence concerns the gene SYN3 and multiple system atrophy.