TGFB1 and hepatocellular carcinoma: Previous studies have reported that isoviolanthin, a C-glycoside flavonoid with apigenin as the parent nucleus, inhibits TGF-β1-induced EMT in hepatocellular carcinoma cells via the deactivation of the TGF-β/Smad and PI3K/Akt/mTOR signaling pathways [39].