The combination of non-effective concentrations of AZD8999 and fluticasone propionate increased the gene expression of GRα and the anti-inflammatory corticosteroid inducible gene mitogen-activated protein kinase phosphatase 1 (MKP1) in neutrophils from healthy and COPD patients (Fig 4A and 4B). Here, DUSP1 is linked to chronic obstructive pulmonary disease.