This CLE formation concept is clinically supported by the fact that the mutation of epidermal-specific lipoxygenases such as 12R-LOX and eLOX3, which are involved in CLE formation, causes a barrier-related disease, autosomal recessive congenital ichthyosis (ARCI) [17, 18]. Here, ALOX12B is linked to autosomal recessive congenital ichthyosis.