FGF-2 mediates neurogenesis and neuronal survival [6, 7], BDNF is centrally involved in synaptic transmission and long-term synaptic plasticity [8], HB-EGF is a physiologic ligand for the EGF receptor (ErbB1) that importantly contribute to neuronal survival [9], and VEGF is a potent neurotrophic, neuroprotective, anti-apoptotic, and mitogenic HBGF [10] involved in the impaired angiogenesis observed in AD [11]. Here, HBEGF is linked to Alzheimer disease.