Accordingly, image analysis of the BDNF-GAGs treated cells showed that AD GAGs induced a slight but significantly higher neuritogenic effect; average neurite length was 12.55 ± 0.32 μm/cell in AD GAGs stimulated cells while it was 8.50 ± 0.95 μm/cell in controls GAG stimulated cells (Fig 4g). This evidence concerns the gene BDNF and Alzheimer disease.