The superiority of gefitinib over chemotherapy was demonstrated in patients with EGFR Mut+ NSCLC enrolled in the IPASS study; the HR for progression/death was 0.48 (95% CI 0.36–0.64), p < 0.001; median PFS 10.9 months vs 7.4 months, respectively) [10]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.