TF and thalassemia: Then we simulated applying the same treatment to a thalassemia major version of the model (kInBM at 25% and kRBCSpleen at 400% their WT values, see previous section) and this resulted in higher iron level in RBC, lower [NTBI], a normalized Tf saturation, normalized liver iron (i. e. similar to WT) as well as lower total body iron, compared to the values before treatment.